基于核酸治疗的药物的前景Pharmaceutical Perspectives of Nucleic acid-based Therapeutics
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作者： Ram I. Mahato 著
出 版 社： Oversea Publishing House
出版时间： 2002-6-1字数：版次： 1页数： 521印刷时间： 2002/06/01开本： 16开印次： 1纸张： 胶版纸I S B N ： 9780415283854包装： 精装内容简介
Pharmaceutical Perspectives of Nucleic Acid-Based Therapy presents a comprehensive account of gene therapy, from development in the laboratory to clinical applications, with an emphasis on cancer and cardiovascular and autoimmune diseases. Internationally acclaimed scientists discuss the potential use of lipids, peptides and polymers for the in vivo delivery of nucleic acids, the genesis of structure-synthesis-function interrelationships and the evolutionary approaches of these gene carriers. The book also addresses the influence of a viable gene expression system on disease by controlling gene regulation, transcription, translation and replication.
Univ. of Tennessee, Memphis. Presents a comprehensive account of design and modulation of gene expression and nucleic acid delivery systems. Includes the possible use of lipids, structure-synthesis-function relationship, and the use of DNA and devices for gene delivery. Contains color plates and halftone illustrations. For research scientists.
作者简介
Ram Mahato is at the University of Tennessee in Memphis, USA and Sung Wan Kim is at the University of Utah, USA.
目录
List of color plates
List of figures
List of tables
List of contributors
Foreword
Preface
1 Basic components of gene expression plasmids
2 Inducible gene expression strategies in gene therapy
3 Modulation of gene expression by antisense oligonucleotides
4 Ribozymes as therapeutic agents and genetic tools
5 Peptide nucleic acids (PNA) binding-mediated target gene transcription
6 Aptamers for controlling gene expression
7 Enzymes acting on DNA breaks and its relevance in nucleic acid-based therapy
8 Compaction and condensation of DNA
9 Structure, dispersion stability and dynamics of DNA and polycation complexes
10 Structure and structure-activity correlations of cationic lipid/DNA complexes: supramolecular assembly and gene delivery
11 Cellular uptake, metabolic stability and nuclear translocation of nucleic acids
12 Nucleocytoplasmic trafficking
13 Optimizing RNA export for transgene expression
14 Naked plasmid DNA delivery of a therapeutic protein
15 Cationic lipid-based gene delivery
16 Peptide-based gene delivery systems
17 Cationic and non-condensing polymer-based gene delivery
18 Device-mediated gene delivery
19 Basic pharmaeokinetics of oligonucleotides and genes
20 Interstitial transport of macromolecules: implication for nucleic acid delivery in solid tumors
21 Hepatic delivery of nucleic acids using hydrodynamics-based procedure
22 Role of CpG motifs in immunostimulation and gene expression
23 Local cardiovascular gene therapy
24 Gene therapy for cardiovascular disease
25 Gene therapy for the prevention of autoimmune diabetes List of color plates
