Drug-DNA Interactions: Structures and Spectra (精装)
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品牌: Kazuo NakamotoMasamichi TsuboiGary D. Strahan
基本信息出版社:WileyBlackwell (2008年9月2日)外文书名:药物-DNA相互作用: 结构与光谱丛书名:Methods of Biochemical Analysis精装:378页正文语种:英语ISBN:0471786268条形码:9780471786269产品尺寸及重量:23.6 x 16 x 2.3 cm ; 681 gASIN:0471786268商品描述内容简介Learn vital information about drug–DNA interactions fromDrug–DNA Interactions: Structures and Spectra, the only comprehensive book written about this topic. Understand the types of structural and bonding information that can be obtained using specific physico–chemical methods and discover how to design new drugs that are more effective than current treatments and have fewer side effects. Find detailed information about X–ray crystallography, NMR spectroscopy, molecular modeling, and optical spectroscopy such as UV–Visible absorption, fluorescence, circular dichroism (CD), flow linear dichroism (FLD), infrared (IR) and Raman spectroscopy.专业书评ACCESSIBLE, COMPREHENSIVE INFORMATION ON DRUG-DNA INTERACTIONS.This informative guide is a thorough source of information on the structural basis of drug-DNA interactions and their underlying empirical evidence. It helps readers understand the underlying mechanisms of the interactions, thus expediting research and aiding in the more efficient design of new and more effective drugs with lesser side effects. With a wealth of information gleaned from diverse studies and combined in a logical, practical format,Drug-DNA Interactions: Structures and Spectra:Describes what types of structural information can be obtained using particular techniques
Classified structural and spectroscopic studies of drug-DNA adducts first by bonding types and then by the structure type of the drug
Covers intercalating drugs, groove-binding drugs, covalent-bonding drugs, strand-breaking drugs, and metal-containing drugs
Focuses on structural and bonding information obtained by using physico-chemical methods (such as X-ray crystallography, NMR spectroscopy, and molecular modeling), and optical spectroscopy (such as UV-Visible absorption, fluorescence, circular dichroism (CD), flow linear dichroism (FLD), and infrared (IR) and Raman spectroscopy)
This is a hands-on reference for professionals in pharmaceutical industries and academia, pharmacologists, organic chemists, biochemists, and bioanalytical chemists. It also helps students in chemistry, biochemistry, and pharmacology understand the complex drug-DNA interactions that could pave the way for tomorrow's breakthrough therapies.